HELPS IMPROVE COGNITIVE FUNCTION AND MEMORY IN ADULTS.
Benefits; Helps improve cognitive function in adults. Helps to improve memory in adults. Helps prevent vitamin B12 or vitamin D deficiency. Provides antioxidants. It is recommended to take VITOLI® MEMORY AND COGNITIVE HEALTH to improve your cognitive health: to prevent memory loss and to prevent cognitive disorders. This product is ideal for sporadic use, for example, to improve memory, as well as for preventive use to maintain your cognitive abilities as you age. VITOLI® MEMORY AND COGNITIVE HEALTH is composed of a clinical dose of concentrated ginkgo biloba extract, vitamins B9, B12 and D3, and Provitol® Complex.
Aging better;
The risk of dementia increases as we age, but about 50% of cases could be prevented (Franke et al, 2013). This state of cognitive health loss is characterized by loss of memory and impaired social and occupational functioning (loss of independence). Dementia also includes Alzheimer's disease, Parkinson's disease, and dementia due to vascular disorders. Smith and Blumenthal (2010) report that antioxidants, vitamin B12, folate (B9) and vitamin D are associated with better cognitive health as we age. Taking a quality extract of ginko biloba is one of the best methods of prevention (Franke et al, 2013; Amieva et al, 2013).
Professionals:
In the Chinese pharmacopoeia, ginkgo is used to treat asthma due to its platelet aggregation factor (PAF) inhibitory effect. Ginkgo extract demonstrates peripheral vasodilator, antioxidant, and neuroprotective effects (Chan et al, 2007; Brondino et al, 2013). A recent study demonstrated anti-inflammatory effects through inhibition of pro-inflammatory cytokine IL-1 production, reduction of I-NOS induction, and nitric oxide release (Brondino et al, 2013.). Ginkgo extracts can decrease plasma concentrations of corticosterone, adrenocorticotrophic hormone, norepinephrine, and epinephrine in different brain regions (Brondino et al, 2013). Ingredients:
Provitol®, olive extract (Olea europaea, fruit) The health benefits of olive oil, particularly on memory and cognitive health, are mainly attributable to its polyphenols (Ghanbari et al, 2012). These multiple health benefits are thought to be related, in part, to the modulation of metabolic pathways of aging (Menendez et al, 2013). The Provitol® Complex formulation is equivalent to 100% of the required dose of hydroxytyrosol for the health claim allowed by EFSA in Europe.
Ginkgo biloba extract Ginkgo biloba is a large tree described as a living fossil because it is the last unchanged representative of a family of trees that became extinct over 300 million years ago. Ginkgo biloba extracts are omnipresent in traditional Asian medicine. They are among the best-selling natural health products in the world and the best-selling over-the-counter medicine in Germany.
Vitamin B9 (folate), B12 and D3 Vitamins B9 and B12 are known to benefit the brain by improving the integrity of brain structures, neurotransmitter functions and indirectly, by reducing homocysteine levels. A recent study (2015) demonstrated a link between vitamin D levels and attention and memory abilities in adults over 65 years of age (Brouwer-Brolsma et al, 2015).
A non-medicinal ingredient refers to any substance added to a natural health product to impart the desired consistency or form to the medicinal ingredients. They are therefore fillers, facilitating the filling of capsules. They do not influence the health benefits of the product.
ProvitolMD est issu d’une technologie brevetée.
DOSE ACTIVE POUR CHAQUE INGRÉDIENT
Chaque capsule contient des ingrédients normalisés :
Provitol, extrait d’olive
(Olea europaea, fruit)……………………………50 mg
(normalisé à 12 % d’hydroxytyrosol;
80 : 1 équivalent à 4 gr d’olives sélectionnées).
Ginkgo biloba
(Feuille)……………………………………………200 mg
(24 % flavoglycosides, 6 % terpéno-lactones ;
50 : 1 équivalent à 10 gr de feuilles séchées).
Acide folique (Folate)……….…………………400 μg
Vitamine B12…………………………………….400 μg
Vitamine D3………………………………………..25 μg
Ingrédients non médicinaux :
cellulose microcristalline,
stéarate de magnésium
Posologie – Adultes :
Prendre une capsule, une fois par jour. Garder hors de la portée des enfants.
Vitoli ne contient aucun gluten, produit laitier, œuf, blé, levure, soya, colorant, aromatisant, édulcorant, ni agent de conservation artificiel.
Garder dans un endroit frais et sec.
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Provitol® is based on a patented technology.
ACTIVE DOSE FOR EACH INGREDIENT
Each capsule contains standardized ingredients:
Provitol, olive extract
(Olea europaea, fruit).................................50 mg
(standardized to 12% hydroxytyrosol;
80 : 1 equivalent to 4 gr of selected olives).
Ginkgo biloba
(Leaf)...................................................200 mg
(24 % flavoglycosides, 6 % terpeno-lactones ;
50 : 1 equivalent to 10 gr of dried leaves).
Folic acid (Folate)...............................400 μg
Vitamin B12...........................................400 μg
Vitamin D3...............................................25 μg
Non-medicinal ingredients:
microcrystalline cellulose,
magnesium stearate
Dosage - Adults:
Take one capsule, once daily. Keep out of reach of children.
Vitoli contains no gluten, dairy, egg, wheat, yeast, soy, color, flavour, sweetener or artificial preservatives.
Keep in a cool, dry place.
N.B. Pour la remettre à votre pharmacien ou votre médecin.
VITOLI MÉMOIRE ET SANTÉ COGNITIVE - PRÉCAUTIONS
Effets secondaires
Les différents ingrédients du produit Vitoli MÉMOIRE ET SANTÉ COGNITIVE ne présentent que peu de toxicité
particulière ou sérieuse. Certains utilisateurs de Ginko biloba auraient rapporté quelques effets secondaires
tels un léger risque d’effet gastro-intestinal, maux de tête, ou étourdissement. La littérature scientifique
rapporte que lors d’un usage à long terme, certains patients auraient présenté des saignements (Ginkgo
biloba*5; observation controversée). De rares utilisateurs de cet ingrédient ont aussi présenté des réactions
allergiques cutanées. Ces réactions et les maux de tête, pourraient être dû à une mauvaise qualité d’extrait;
présence de l’acide gingkolique provenant du fruit ou de la branche et normalement absent des bons extraits
de feuilles. Les informations cliniques dont nous disposons actuellement nous montrent que Vitoli MÉMOIRE
ET SANTÉ COGNITIVE présente un profil d’effets secondaires rassurant.
Contrindications
Le produit Vitoli MÉMOIRE ET SANTÉ COGNITIVE devait être évité (arrêter durant au moins 7 jours ou selon
l’avis du médecin) chez les patients devant subir une chirurgie, opération, greffe ou autre intervention à risque
de saignement. Il serait aussi contrindiqué chez les patients sous antiplaquettaires ou anticoagulants (*4). De
plus chez un patient prenant de la Nifédipine (Adalat ou autre générique), une surveillance accrue serait
recommandée puisqu’il y a possibilité d’augmentation de l’effet de la Nifédipine par le Ginkgo Biloba (*3).
Éviter le produit chez les patients ayant déjà présenté une allergie au sumac, herbe à puce, et pelure de
mangue. Bien que les cas répertoriés soient anecdotiques (*2 et *7), il pourrait par précaution être évité chez
les patients épileptiques sous anticonvulsivants, autant à cause du Ginkgo que de l’acide folique.
Interactions
Augmentation possible de l’effet de la nifédipine (*3). Augmentation possible de l’effet des antiplaquettaires.
Augmentation possible de l’effet des anticoagulants (*4). Diminution possible de l’effet de certains
anticonvulsivants (phénytoin, phénobarbital, primidone). Le produit ne devrait pas être utilisé chez les rares
patients qui sont sous l’un des deux (2) médicaments suivants : BUROSOMAB et ERDAFITINIB.
Les extraits de qualité d’olive pourraient abaisser la pression artérielle, améliorer la gestion du glucose et
réduire la coagulation sanguine. Toutefois, la dose utilisée est la dose alimentaire consommée en moyenne
dans la diète méditerranéenne et elle n’est pas reliée à aucun effet significatif d’interactions. Santé Canada
n’a pas rapporté ce risque comme étant significatif.
Grossesse et allaitement
Il apparaît prudent d’éviter la prise de Vitoli MÉMOIRE ET SANTÉ COGNITIVE durant la grossesse ou
l’allaitement .
www.vitoli.ca - professionnels@vitoli.ca
(438) 794-3372
Mise en garde
Le contenu des plantes médicinales varie naturellement ou selon les conditions d’extraction. Il y a donc
beaucoup de variations dans la composition des ingrédients disponibles d’une marque de produits à une
autre. Il est fortement recommandé d’utiliser des produits de qualité, ceux-ci étant standardisés pour contenir
les quantités suffisantes de substances actives pour chaque plante, ce qui assure leur efficacité, confirme
l’origine de la plante et la sécurité. La réglementation canadienne n’oblige pas les entreprises à respecter ces
standards; la majorité des extraits de plante sur le marché ne sont pas standardisés. Idunn Technologies
utilisent uniquement des ingrédients standardisés pour les produits Vitoli et les informations contenues dans
ce document s’appliquent uniquement à ces produits.
Si vous prenez des médicaments d’ordonnance et avez des doutes, vérifiez avec votre pharmacien s’ils sont
compatibles avec le produit Vitoli MÉMOIRE ET SANTÉ COGNITIVE avant d’en consommer.
Il est toujours possible qu’une hypersensibilité (ex : allergie) à l’un des ingrédients de la préparation se
manifeste. Dans un tel cas il est recommandé de cesser l’utilisation et de consulter un professionnel de la
santé si des symptômes sérieux d’allergie persistent.
André Perreault, pharmacien,
Services professionnels
Idunn Technologies
Révisé par Jean-Yves Dionne,
Académie de l’apothicaire (www.apothicaire.ca)
Références :
1-Grosesse et allaitement – Guide thérapeutique, (2 ème édition, 2013)
* 2 - Granger AS. Ginkgo biloba precipitating epileptic seizures. Age Ageing 2001;30:523-5
* 3- Yoshioka, et al. Studies on interactions between functional foods or dietary supplements and
medicines. IV. Effects of ginkgo biloba leaf extract on the pharmacokinetics and pharmacodynamics of nifedipine in
healthy volunteers. Biol.Pharm.Bull. 2004;27(12):2006-2009.
*4- Gaudineau C, Beckerman R, Welbourn S, Auclair K. Inhibition of human P450 enzymes by multiple
constituents of the Ginkgo biloba extract. Biochem Biophys Res Comm 2004;318:1072–8
*5- Bent S, Goldberg H, Padula A, Avins AL. Spontaneous bleeding associated with Ginkgo biloba: a case report and
systematic review of the literature. J Gen Intern Med 2005;20;657-61.
*6- Dugoua JJ, Mills E, Perri D, Koren G. Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactation.
Can J Clin Pharmacol 2006;13:e277-84.
*7- Gregory PJ. Seizure associated with Ginkgo biloba? Ann Intern Med 2001;134:344.
8.-Natural Medicines Comprehensive Database, Therapeutic Research Faculty, 2018
9.-The Review of Natural Products, 6 ième édition, 2010
10.-Santé Canada, Base de données des produits de santé naturels
11.-Facts and Comparisons, The Lawrence review of natural products, 1998 12.-Rx
||
N.B. To give to your pharmacist or physician.
VITOLI MEMORY AND COGNITIVE HEALTH - PRECAUTIONS
Side effects
The different ingredients of Vitoli MEMORY AND COGNITIVE HEALTH have little or no specific or serious toxicity.
or serious toxicity. Some users of Ginko biloba have reported some side effects such as a slight risk of gastric effect
such as a slight risk of gastrointestinal effects, headaches, or dizziness. The scientific literature
reports that during long-term use, some patients have experienced bleeding (Ginkgo
biloba*5; controversial observation). Some rare users of this ingredient have also experienced skin
allergic skin reactions. These reactions and the headaches could be due to the poor quality of the extract;
presence of gingkolic acid coming from the fruit or the branch and normally absent from good extracts
of leaves. The clinical information we have at present shows that Vitoli MEMORY
AND COGNITIVE HEALTH has a reassuring side effect profile.
Contraindications
Vitoli MEMORY AND COGNITIVE HEALTH should be avoided (stopped for at least 7 days or as advised by the doctor) in
physician's advice) in patients undergoing surgery, operation, transplantation or any other procedure with risk of bleeding.
bleeding. It would also be contraindicated in patients on antiplatelet or anticoagulant drugs (*4). From
In addition, in a patient taking Nifedipine (Adalat or other generic), increased monitoring would be
recommended since there is a possibility of an increase in the effect of Nifedipine by Ginkgo Biloba (*3).
Avoid the product in patients with a previous allergy to sumac, poison ivy, and mango peel.
mango peel. Although reported cases are anecdotal (*2 and *7), it should be avoided as a precaution in
epileptic patients on anticonvulsants, both because of the Ginkgo and the folic acid.
Interactions
Possible increase in the effect of nifedipine (*3). Possible increase in the effect of antiplatelet drugs.
Possible increase in the effect of anticoagulants (*4). Possible decrease in the effect of some
anticonvulsants (phenytoin, phenobarbital, primidone). The product should not be used in the rare
patients who are on one of the following two (2) drugs: BUROSOMAB and ERDAFITINIB.
Olive quality extracts may lower blood pressure, improve glucose management and reduce blood clotting.
reduce blood clotting. However, the dose used is the average dietary dose consumed
in the Mediterranean diet and is not related to any significant interaction effects. Health Canada
has not reported this risk as significant.
Pregnancy and breastfeeding
It appears prudent to avoid taking Vitoli MEMORY AND COGNITIVE HEALTH during pregnancy or lactation.
breast-feeding.
www.vitoli.ca - professionnels@vitoli.ca
(438) 794-3372
Cautionary note
The content of medicinal plants varies naturally or according to the extraction conditions. Therefore, there are
There is therefore a lot of variation in the composition of the ingredients available from one brand of product to another.
another. It is strongly recommended to use quality products, which are standardized to contain
sufficient quantities of active substances for each plant, which ensures their effectiveness, confirms
the origin of the plant and safety. Canadian regulations do not require companies to meet these standards.
standards; the majority of plant extracts on the market are not standardized. Idunn Technologies
uses only standardized ingredients for its Vitoli products and the information contained in this document applies only to those
this document applies only to these products.
If you are taking prescription drugs and are unsure, check with your pharmacist to see if they are
compatible with Vitoli MEMORY AND COGNITIVE HEALTH before taking it.
It is always possible that a hypersensitivity (ex: allergy) to one of the ingredients of the preparation may occur.
to one of the ingredients of the preparation. In such a case, it is recommended to stop using the product and to consult a health professional if serious symptoms of allergy occur.
if serious allergy symptoms persist.
André Perreault, pharmacist,
Professional Services
Idunn Technologies
Reviewed by Jean-Yves Dionne,
Academy of Apothecaries (www.apothicaire.ca)
References:
1-Fat and Breastfeeding - A Therapeutic Guide, (2 nd Edition, 2013)
* 2 - Granger AS. Ginkgo biloba precipitating epileptic seizures. Ageing 2001;30:523-5
* 3- Yoshioka, et al. Studies on interactions between functional foods or dietary supplements and
medicines. IV. Effects of ginkgo biloba leaf extract on the pharmacokinetics and pharmacodynamics of nifedipine in
healthy volunteers. Biol.Pharm.Bull. 2004;27(12):2006-2009.
*4- Gaudineau C, Beckerman R, Welbourn S, Auclair K. Inhibition of human P450 enzymes by multiple
constituents of the Ginkgo biloba extract. Biochem
Biophys Res Comm 2004;318:1072-8
*5- Bent S, Goldberg H, Padula A, Avins AL. Saignement spontané associé au Ginkgo biloba : rapport de cas et revue systématique de la littérature.
systematic review of the literature. J Gen Intern Med 2005;20;657-61.
*6- Dugoua JJ, Mills E, Perri D, Koren G. Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactation.
Can J Clin Pharmacol 2006;13:e277-84.
*7- Gregory PJ. Crise d'épilepsie associée au Ginkgo biloba ? Ann Intern Med 2001;134:344.
8.-Natural Medicines Comprehensive Database, Faculté de recherche thérapeutique, 2018.
9.-The Review of Natural Products, 6 ième édition, 2010
10.-Santé Canada, Base de données des produits de santé naturels.
11.-Faits et comparaisons, The Lawrence review of natural products, 1998 12.-Rx
